Natural Luteolin Powder is a premium plant-derived flavonoid compound widely recognized for its diverse biological activities and health-promoting properties. Naturally occurring in a variety of plants such as sweet peppers, perilla, and celery, luteolin belongs to the phytoestrogen class of compounds. In nature, it predominantly exists in the form of glycosides across various vegetables, fruits, and herbs. Historically, its name derives from its initial isolation from plants of the genus Luteolin within the family Fabaceae.
Characterized by its distinct yellow needle-like crystal structure, our Natural Luteolin Powder is soluble in organic solvents such as ethanol and methanol, as well as in alkaline solutions. Extensive scientific literature indicates that luteolin exhibits potent antioxidant, anti-inflammatory, and uric acid-lowering effects, making it a highly sought-after active ingredient for dietary supplement formulation, functional foods, and nutraceutical applications.
Product Specifications and Quality Standards
To ensure consistency, purity, and formulation stability, our Natural Luteolin Powder undergoes rigorous analytical testing. The product is standardized to contain a high concentration of the active flavonoid, with no added excipients or foreign substances.
| Item | Specification |
|---|---|
| Identification | TLC, HPLC, Conforms |
| Assay | ≥83% (External standard) |
| Appearance | Fine Powder |
| Color | Light Yellow |
| Excipient | None |
| Particle Size | 100% Through 80 mesh |
| Loss on Drying (5h at 105℃) | ≤5.0% |
| Ash Content | ≤8.0% |
Source, Extraction Process, and Physicochemical Properties
At Extracts China, we prioritize traceability and natural integrity. Our Natural Luteolin Powder is exclusively extracted from premium-grade peanut shells (Arachis hypogaea). By utilizing this specific botanical source, we leverage a sustainable raw material matrix that yields a high concentration of the target flavonoid.
Our state-of-the-art extraction and purification process is meticulously designed to preserve the active component without the addition of any foreign substances, ensuring the product's natural origin and high purity. The resulting extract presents as a light yellow, fine powder with optimal particle size distribution (100% through 80 mesh), which guarantees excellent flowability and uniformity for manufacturing processes. Due to its specific physicochemical profile, luteolin is soluble in organic solvents (ethanol, methanol) and alkaline solutions, providing excellent formulation compatibility for various delivery systems, including capsules, tablets, and powdered blends.
Core Functional Benefits and Scientific Mechanisms
Natural Luteolin Powder exhibits a broad spectrum of health benefits, including intestinal uric acid reduction, cardioprotective and neuroprotective effects, alongside antibacterial, anti-allergic, and anti-diabetic properties.
Uric Acid Reduction and Renal Protection
Luteolin demonstrates potent uric acid-lowering and antioxidant bioactivity. Research indicates that luteolin facilitates uric acid excretion, mitigates renal injury, and reduces apoptosis induced by hyperuricemia. It improves renal outcomes by regulating uric acid transporters, inhibiting xanthine oxidase (XO) activity, and activating the renal SIRT1/6 cascade along with its downstream Nrf2-mediated antioxidant pathways. Furthermore, in vivo murine studies confirm that luteolin alleviates renal injury in hyperuricemic nephropathy models. It achieves this by activating uric acid excretion and the Nrf2/HO-1/NQO1 antioxidant pathway, while simultaneously suppressing hepatic xanthine oxidase activity.
Cardiovascular and Cardiomyocyte Protection
Preclinical research highlights luteolin's role in protecting cardiac tissue. Knocking down NLRP3 has been shown to enhance the viability of LPS-treated H9c2 cells (derived from rat embryonic ventricular tissue with partial cardiomyocyte characteristics) while reducing LPS-induced apoptosis and the release of inflammatory factors. Luteolin is thought to mitigate inflammatory damage by downregulating NLRP3, thereby protecting cardiomyocytes from LPS-induced apoptosis and inflammatory cascades. These findings strongly support the utilization of luteolin for improving myocarditis conditions and validate NLRP3 as a potential therapeutic target.
Neuroprotection and Cognitive Health
In vitro studies reveal that Natural Luteolin Powder improves the condition of C6 glioma cells and BV2 microglia in rats, thereby alleviating symptoms associated with Alzheimer's disease. Luteolin actively inhibits LPS-induced cell proliferation, the production of inflammatory cytokines, and endoplasmic reticulum stress, effectively alleviating cognitive impairment and limiting neuronal damage. Ahmad et al. found that luteolin may mitigate oxidative stress, neuroinflammation, apoptosis, amyloid beta production, and synaptic dysfunction in mice injected with amyloid beta protein, primarily through the inhibition of JNK signaling.
Anti-Diabetic Properties
Emerging research has identified that a specific luteolin derivative—the 6,8-guanidino-rutin quinone-chromium complex (GLQ·Cr)—can effectively regulate the PPAR signaling pathway in the liver and positively modulate the gut microbiota. This compound has been shown to improve glucose metabolism in type 2 diabetic mouse models, offering new therapeutic hope for the prevention and dietary management of type 2 diabetes.
Industry Applications and Formulation Compatibility
Natural Luteolin Powder is a versatile active ingredient utilized across multiple sectors of the health and nutrition industry. Its excellent stability and solubility profile make it compatible with various manufacturing matrices.
- Chronic Bronchitis Formulations: Luteolin powder is primarily formulated into respiratory health products designed to stop coughs, dispel phlegm, and diminish inflammation.
- Healthy Inflammation Management: According to clinical studies, luteolin helps support the inhibition of the inflammatory response of microglial cells. This characteristic allows formulators to develop products aimed at maintaining healthy inflammatory conditions throughout the body.
- Memory and Cognitive Support: Early research demonstrates that luteolin can reduce the brain's production of inflammatory cytokines. This mechanism is highly beneficial for formulations targeting memory support and maintaining cognitive recall as consumers age.
- Antioxidant Support Systems: Natural luteolin powder exhibits robust antioxidant activity, which is particularly advantageous for protecting muscle and nerve cells from oxidative stress. It is an ideal ingredient for daily antioxidant and anti-aging supplements.
Manufacturing Excellence and Supply Chain Reliability
As a dedicated ingredient partner specializing in herbal extract powders and food supplements, Extracts China has devoted over six years to the research, development, production, and distribution of premium botanical ingredients. Our purpose is to bring unique, cost-effective, and ecologically sustainable products to the global market.
To support our B2B clients, we offer comprehensive OEM services, including capsule filling, tableting, and the blending of pre-made powders, allowing brands to scale their product lines efficiently. Furthermore, we maintain strategically located warehouses in both Europe and the United States, ensuring convenient, fast, and reliable local pickup for our international customers. Our standardized production ensures high batch-to-batch consistency, traceability, and compliance with international quality benchmarks.
Packaging, Storage, and Delivery Information
Storage Recommendations: Store Natural Luteolin Powder in a cool, dry place, away from direct sunlight and moisture. Ensure the container is tightly sealed to preserve the product's physicochemical stability and extend its shelf life.
Delivery Time:
| Quantity (Kilograms) | Estimated Time (Days) |
|---|---|
| 2 - 1000 | 3 |
| 1000 - 10000 | 5 |
| > 10000 | Negotiable |
Partner with Extracts China for Your Raw Material Needs
Extracts China is committed to building your brand by providing superior raw materials. Our high-purity Natural Luteolin Powder is trusted by manufacturers, importers, and distributors worldwide for its proven efficacy, rigorous quality control, and competitive pricing.
To request a free sample or inquire about bulk pricing and formulation specifics, please contact our technical sales team today: [email protected]
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