Octacosanol powder (chemical formula C₂₈H₅₈O) is a highly valued white crystalline substance naturally derived from sources such as rice bran wax, beeswax, and sugarcane wax. As an internationally recognized "energy factor," this long-chain aliphatic alcohol offers unique physiological benefits. Its distinct physical characteristics—namely its insolubility in water and solubility in organic solvents—make it a versatile ingredient for various health applications.
Extracts China utilizes premium rice bran wax and non-GMO sugarcane wax as the optimal raw materials for producing high-quality Octacosanol powder. Through advanced engineering, we deliver a natural plant extract free from chemical synthesis or solvent residues, ensuring maximum efficacy and safety for global B2B procurement.
Sourcing & Advanced Manufacturing Process
Our Octacosanol powder is derived from natural, non-GMO rice bran wax and sugarcane wax. To preserve the integrity of the active compounds while achieving exceptionally high purity levels, Extracts China employs a rigorous, state-of-the-art extraction process. By utilizing low-temperature fractional crystallization combined with molecular distillation, we effectively isolate and concentrate the target active compounds without degrading them through thermal stress.
This precision manufacturing allows us to offer standardized Octacosanol content of ≥60%, ≥70%, or ≥90% (customizable to specific formulation requirements), with total higher alcohols (Policosanol) consistently maintained at ≥98.00%.
Uncompromising Quality Control & Purity
Our quality control protocols ensure that all impurities, including acid value, ash content, and heavy metals, are well below national and European/American pharmacopeial standards. With lead (Pb) strictly limited to ≤3 mg/kg and arsenic (As) ≤1.5 mg/kg, our Octacosanol powder is highly suited for food-grade, health supplement-grade, and pharmaceutical-grade applications.
Technical Specifications & Quality Standards
| Item | Specification |
|---|---|
| Physical Characteristics | |
| Appearance | White to off-white powder |
| Excipient | None |
| Chemical & Analytical Data | |
| Fatty Acid (mg KOH/g) | < 1.5% |
| Loss on Drying | ≤ 0.5% |
| Ash Content | ≤ 0.1% |
| Melting Point | 80–83℃ |
| Solubility | Insoluble in water; soluble in aliphatic and aromatic compounds at 70–80℃ |
| Particle Size | 100% through 80 mesh |
| Extract Solvent | 50% ethanol, 50% water |
| Assay (GC) | |
| Octacosanol | Customizable (≥60%, ≥70%, ≥90%) |
| Total Alcohols (Policosanol) | ≥ 98.00% |
Physicochemical Properties & Formulation Compatibility
Octacosanol powder presents as a free-flowing, white to off-white crystalline powder with a melting point between 80℃ and 83℃. Due to its hydrophobic nature, it is insoluble in water but achieves excellent solubility in aliphatic and aromatic compounds at elevated temperatures (70–80℃).
For formulation developers, this suggests excellent compatibility with lipid-based delivery systems, emulsions, and softgel matrices. The fine particle size (100% passing through an 80 mesh screen) ensures uniform distribution within powder blends, dry granulation, and capsule-filling processes, providing excellent flowability and mixability for dietary supplement manufacturing.
Scientifically Backed Functions & Mechanisms of Action
Anti-Inflammatory Support
Within a concentration range of 10–100 μg/mL, Octacosanol exhibits a dose-dependent anti-inflammatory effect on lipopolysaccharide-stimulated RAW264.7 macrophages. This mechanism is achieved by inhibiting the phosphorylation of p38, JNK, and ERK1/2 proteins, thereby effectively blocking the MAPK/NF-κB/AP-1 signaling pathway, which is critical to the body's inflammatory response.
Antithrombotic & Cardiovascular Protection
Octacosanol powder serves as a potent antiplatelet aggregation agent, helping to prevent and treat various cardiovascular diseases caused by thrombosis resulting from platelet aggregation in blood vessels. It actively reduces blood levels of thromboxane B2 while increasing levels of 6-ketoprostaglandin FⅠα. Furthermore, it inhibits collagen, arachidonic acid, adenosine diphosphate (ADP), and epinephrine-induced platelet aggregation without affecting coagulation factors or interacting with warfarin, making it a safe cardiovascular adjunct.
Reducing Ischemic Stroke Recurrence
The 5-year LTEPOI study (Secondary Prevention of Ischemic Stroke) demonstrated significant clinical outcomes. Daily administration of 10–20 mg of PPG (polyparadecanol) significantly improved patient quality of life (measured by increased CNS scores), reduced systolic blood pressure by 15.1 mmHg (1 mmHg = 0.133 kPa), and notably decreased ischemic stroke recurrence by 80%.
Metabolic Conversion & Bioavailability
Metabolic conversion is a key factor influencing the bioavailability of long-chain alcohols. The metabolic pathway of Octacosanol primarily involves β-oxidation, closely linked to fatty acid metabolism. In the liver, both Octacosanol and its oxidation product exhibit significantly higher concentrations than in plasma.
Once activated by acyl-CoA synthase, a portion of Octacosanol undergoes β-oxidation within hepatic peroxisomes, yielding short-chain saturated fatty acids such as myristic acid, palmitic acid, and stearic acid. These saturated products are then desaturated at specific molecular positions by desaturase enzymes, converting into unsaturated fatty acids like palmitoleic acid and oleic acid. Among these metabolites, palmitic acid exhibits the highest concentration in plasma, contributing to the systemic energy-boosting effects.
Diverse Industry Applications
Functional Foods & Dietary Supplements
Recognized as an elite sports supplement, lipid-lowering functional food, and astronaut-specific nutritional agent, Octacosanol powder is recommended at a daily dose of 5–10 mg, with established safety profiles showing no adverse side effects. It is ideal for energy-boosting pre-workout formulations, endurance enhancers, and cardiovascular health supplements.
Pharmaceuticals & Health Products
Widely utilized in the pharmaceutical sector to help treat osteoporosis and hypercholesterolemia, Octacosanol is also formulated into anti-fatigue and hypoxia-tolerance medications. Its efficacy is globally recognized; for instance, Cuba's Octacosanol powder mixture extracted from sugarcane wax has received FDA approval for specific therapeutic applications.
Cosmetics & Personal Care
When formulated into hair conditioners and premium face creams, Octacosanol promotes localized blood circulation and cellular activation. It improves skin elasticity and is utilized in regimens designed to prevent and treat eczema and acne, making it a highly valued active ingredient in dermocosmetics.
Agriculture & Animal Feed
As a poultry feed additive, it demonstrates significant value in livestock management. Administered at 5 mg/kg for laying hens and 24 mg/kg for broilers, it enhances egg production, improves meat quality metrics, and favorably regulates the gut microbiota of the animals, promoting overall flock health.
Packaging, Storage, and Lead Times
To preserve product integrity, Octacosanol powder should be stored in a cool, dry place, away from direct sunlight and moisture. We provide standard export-grade packaging tailored to international shipping requirements, ensuring product stability and traceability throughout the supply chain.
| Quantity (Kilograms) | Estimated Lead Time (Days) |
|---|---|
| 1 – 10 | 3 |
| 10 – 50 | 5 |
| > 50 | Negotiation |
Partner with Extracts China for Your Raw Material Needs
Extracts China is dedicated to helping you build your brand. By choosing our Octacosanol powder, you are securing a high-purity, scientifically backed, and meticulously manufactured raw material. Our commitment to quality stability, complete supply chain traceability, and standardized production makes us the preferred partner for manufacturers, importers, brand owners, and distributors worldwide.
For more details, bulk pricing, or formulation consultations, please feel free to contact us:
Email: [email protected]
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