Osthole Powder

Osthole Powder is a premier botanical extract derived from the fruits of Cnidium monnieri, a plant with a long-standing history in traditional herbal medicine. As a naturally occurring coumarin compound, osthol is the most abundant active ingredient in the plant, typically accounting for 1.0% to 3.0% of the dried fruit's weight. Recognized for its core pharmacological value, Osthole Powder is highly sought after by dietary supplement manufacturers, functional food developers, and cosmetics formulators worldwide.

Botanical Source and Active Ingredient

Sourced from premium Cnidium monnieri fruit, Osthole Powder leverages the synergistic potential of natural coumarins. The primary active compound, osthol (C15H16O3), is a methoxylated coumarin derivative. Extracts China ensures that the raw materials are harvested at their peak botanical maturity to guarantee the highest natural yield of osthol before entering the extraction phase.

Advanced Manufacturing and Extraction Process

Extracts China utilizes state-of-the-art processing technology to produce Osthole Powder of exceptional purity. Our manufacturing process relies on supercritical CO₂ extraction combined with macroporous resin purification within a closed-loop system. This advanced methodology offers several distinct advantages:

• Zero Solvent Residue: The closed-loop purification guarantees no organic solvent residue in the final product.
• Superior Yield: The osthol yield achieves 3.48%, which is 2.1 times higher than traditional water extraction methods.
• Real-Time Monitoring: The entire process is monitored by real-time HPLC (High-Performance Liquid Chromatography) to actively track active ingredient concentrations.

Rigorous Quality Control and Traceability

As a GMP-certified facility, Extracts China enforces pharmacopoeia-grade quality control standards. Our Osthole Powder fully complies with the 2025 edition of the Chinese Pharmacopoeia. We maintain a batch-to-batch Relative Standard Deviation (RSD) of ≤2.0%, ensuring unparalleled consistency for commercial formulation.

Our quality assurance protocols include:

• High-Purity Standards: High-purity (≥95%) products feature a total impurity content of <0.5%, meeting stringent standards for high-end pharmacopoeia formulations.
• Residual Control: Solvent residue is strictly maintained at <5ppm.
• Complete Traceability: We provide full-chain traceability from raw botanical sourcing to production, laboratory testing, and warehousing. A Certificate of Analysis (COA), HPLC chromatograms, and microbiological reports accompany each batch.

Pharmacological Effects and Functional Benefits

The active compound in Extracts China's Osthole Powder has been extensively studied for its diverse pharmacological properties. While ongoing research continues to unveil new therapeutic potentials, current scientific literature highlights the following functional benefits:

Anti-Inflammatory and Antioxidant Properties

Osthole has demonstrated significant anti-inflammatory effects by inhibiting the production of inflammatory mediators and modulating immune responses. Concurrently, its robust antioxidant activity helps scavenge free radicals, protecting cells from oxidative stress and reducing cellular damage.

Respiratory and Cardiovascular Support

• Bronchodilator: Total coumarins from Cnidium monnieri exhibit notable bronchodilator activity. They significantly reduce or eliminate wheezing in asthmatic patients, increase peak expiratory flow rate, and improve pulmonary ventilation, while also providing expectorant benefits.
• Cardiac Inhibition and Vasodilatory Effects: Experimental results indicate that Cnidiosolin simultaneously exhibits cardiac inhibitory effects by modulating myocardial contractility and vasodilatory effects. By lowering blood pressure, reducing preload and afterload on the heart, and decreasing myocardial oxygen consumption, it effectively relaxes vascular smooth muscle.

Cellular and Neurological Health

• Anti-Cancer Activity: Osthole has shown promise in inhibiting cancer cell growth and proliferation, inducing apoptosis (programmed cell death), and suppressing tumor angiogenesis.
• Neuroprotection: Preliminary research suggests osthole protects neurons from damage, promotes neuronal survival, and may offer therapeutic potential for neurodegenerative conditions.

Bone and Dermatological Health

• Bone Health: Studies suggest osthole enhances bone formation and inhibits bone resorption, presenting a promising natural intervention for conditions like osteoporosis.
• Antifungal: In vitro tests confirm that osthole, bergapten, and isoharpin exhibit strong activity against Trichophyton mentagrophytes (a common dermatophyte).

Hormonal and Antiparasitic Activity

• Sex Hormone-Like Effects: Ethanol extracts of Cnidium monnieri, when administered subcutaneously to mice for 32 consecutive days, have been shown to prolong the estrus phase, induce estrus in castrated mice, and increase ovarian and uterine weights. Extracts also demonstrate androgen-like effects by increasing prostate, seminal vesicle, and levator ani muscle weight in mice, without corrosive effects on vaginal mucosa.
• Anti-Trichomonas: While single-ingredient efficacy against Trichomonas vaginalis is weak, Cnidiosin exhibits in vitro activity with a minimum effective concentration of 1.12 mg/mL. Compound formulations demonstrate excellent clinical results for trichomoniasis vaginitis.

Product Specifications

Extracts China offers customized Osthole Powder in multiple grades to suit diverse formulation needs, ranging from dietary supplements to high-end pharmacological research.

Industry Applications and Formulation Compatibility

Osthole Powder is a versatile raw material with excellent formulation compatibility across various B2B sectors:

1. Dietary Supplements: Highly compatible with capsule, tablet, and powder matrices. It is frequently formulated to support bone density, sexual health, cardiovascular function, and overall vitality.
2. Functional Foods and Beverages: Can be seamlessly incorporated into functional formulations such as energy bars, protein shakes, herbal teas, and nutritional drinks to provide a natural health boost.
3. Skincare Products: Its antioxidant and dermatological benefits make it a premium ingredient for anti-aging creams, serums, lotions, and masks targeting acne, eczema, and general skin rejuvenation.
4. Topical Formulations: Ideal for transdermal applications, including gels, ointments, and creams, enabling targeted delivery for joint discomfort, muscle inflammation, and dermatological conditions.
5. Traditional Medicine: Continues to be a staple in traditional East Asian herbal remedies and compound formulations.
6. Research and Development: Widely utilized by scientists for in vitro and in vivo studies exploring its pharmacological properties, mechanisms of action, and potential therapeutic applications.

Storage and Packaging Guidelines

To maintain the physicochemical stability of Osthole Powder, it should be stored in a cool, dry, and light-protected environment.

• Recommended Storage Conditions: Temperature below 25°C; relative humidity ≤60%; avoid direct sunlight.
• Shelf Life: 24 months from the date of manufacture when stored unopened in its original packaging. Once opened, the product should be used promptly and resealed tightly to prevent moisture absorption and degradation of active ingredients.
• Standard Packaging: 25kg/drum, optimized for bulk B2B orders and global shipping.

Frequently Asked Questions (FAQ)

Q: What specifications of Osthole products does Extracts China offer?
A: Extracts China provides Osthole raw materials tailored to diverse applications, including 10%, 20%, 50%, and 98% (HPLC) purities. The high-purity 98% grade is specifically suited for formulation development, functional research, and high-end dietary supplement applications. The standard product form is a light yellow to off-white fine powder. We support customization for particle size, bulk density, packaging specifications, and pre-blending services.

Q: How does Extracts China ensure the quality consistency of Osthole products?
A: We operate a comprehensive quality control system enforcing strict testing from raw material procurement to final product release. This includes HPLC active ingredient content testing, moisture and ash content analysis, heavy metal screening, pesticide residue testing, microbial limit testing, and solvent residue testing. Each batch is accompanied by a COA, MSDS, and relevant technical documentation to guarantee stability and consistency.

Q: What are the storage conditions and shelf life of Osthole?
A: Store in a cool, dry, light-protected area below 25°C with relative humidity ≤60%. Under proper conditions with unopened packaging, the shelf life is 24 months. Once opened, reseal immediately and use as soon as possible to preserve the active coumarins.

Why Choose Extracts China?

Extracts China is a trusted ingredient partner specializing in herbal extract powders and nutritional food supplements. With over 6 years of dedicated experience in research, development, production, and global sales, our purpose is to deliver unique, cost-effective, and ecologically conscious products to the market.

We operate an annual production capacity of ≥500 tons, including ≥50 tons of high-purity (≥95%) osthol. Long-term partnerships with agricultural farmers mitigate raw material fluctuations, ensuring continuous supply and price stability. Our GMP, ISO 9001, and ISO 22000 certified facility—along with EU CEP certified products—supports compliant global sales.

Related Products: Men's Health Raw Materials

Delivery and Logistics

For more details, please feel free to contact us: [email protected]

Ashley Kensington