Nobiletin Powder is a premium, highly concentrated raw material derived from the peel of various citrus fruits. As a specialized citrus flavonoid, it stands out in the global nutraceutical market due to its exceptional purity profile and distinct biological activity. Recognized for its potent antioxidant and anti-inflammatory properties, Nobiletin Powder serves as a critical ingredient for manufacturers targeting metabolic health, cognitive support, and cardiovascular wellness.
Unmatched Sourcing and Manufacturing Excellence
Extracts China operates a dedicated citrus peel processing base, handling over 5,000 tons of fresh raw material annually. To guarantee uninterrupted supply and eliminate quality fluctuations caused by seasonal raw material shortages, our facility is equipped with advanced low-temperature cold storage (-18℃). This infrastructure ensures year-round batch-to-batch consistency and raw material traceability.
Our Nobiletin Powder boasts an impressive purity of ≥98% (verified via HPLC testing), significantly surpassing the industry standard of 70%-90%. We strictly control impurities (such as hesperidin and other flavonoids) to ≤1.5%, moisture to ≤0.5%, and heavy metals (lead, arsenic, mercury) to <1ppm. These rigorous specifications meet USP-NF and EP pharmacopoeia standards. A comprehensive Certificate of Analysis (COA) is provided for every batch, ensuring all data is fully verifiable for our B2B partners.
Product Specifications
| Item | Specification |
|---|---|
| Marker Compounds | Nobiletin ≥30.00% |
| Appearance | Fine Powder |
| Color | Brown |
| Odor | Characteristic |
| Taste | Characteristic |
| Physical Characteristics | |
| Sieve Analysis | 98% pass 80 mesh |
| Loss on Drying | ≤5.0% |
| Ash Content | ≤5.0% |
| Bulk Density | 45-65g/100ml |
Core Functions and Mechanisms of Action
Extensive research and preclinical studies highlight the multifaceted bioactivity of Nobiletin Powder. Its efficacy spans several critical physiological pathways:
1. Antioxidant and Free Radical Scavenging
Nobiletin activates the Nrf2 signaling pathway, significantly enhancing SOD and glutathione peroxidase activity to scavenge ROS free radicals. It demonstrates an antioxidant capacity three times greater than vitamin C and twice that of vitamin E, effectively reducing oxidative stress damage (Citation: Frontiers in Pharmacology, 2024).
2. Anti-inflammatory and Pathway Inhibition
This potent citrus extract targets and inhibits the NF-κB, MAPK, and COX-2 inflammatory pathways. By reducing the release of pro-inflammatory factors such as IL-1β, IL-6, and TNF-α, it helps alleviate chronic inflammation, including arthritis and neuroinflammation (Citation: PubMed, 2025).
3. Neuroprotective and Cognitive Improvement
Nobiletin Powder can successfully penetrate the blood-brain barrier. It reduces Aβ amyloid protein deposition and inhibits tau protein hyperphosphorylation, directly improving learning and memory abilities. Animal experiments have confirmed its capacity to alleviate cognitive decline in Alzheimer's disease models (Citation: Journal of Drug Delivery and Therapeutics, 2025; PMC, 2025).
4. Cardiovascular Protection and Bone Health Support
Nobiletin dilates blood vessels, improves microcirculation, reduces vascular permeability, and prevents atherosclerosis. Concurrently, it inhibits osteoclast activity, reducing bone loss and maintaining bone density (Citation: Acerchem, 2025).
5. Metabolic Regulation and Organ Protection
By activating the AMPK pathway, Nobiletin improves insulin resistance and lowers blood sugar. It inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower triglycerides. Furthermore, it alleviates hepatic steatosis and liver fibrosis, offering comprehensive liver and kidney protection (Citation: Frontiers in Pharmacology, 2024).
Formulation Advantages and Application Scenarios
Exceptional Physicochemical Properties and Compatibility
Nobiletin Powder presents as a white to pale yellow crystalline powder with excellent flowability and uniform particle size (D90≤50μm). It is non-hygroscopic and highly stable, retaining ≥95% activity after 24 months of storage at room temperature away from light. Highly lipid-soluble, it dissolves directly in vegetable oils and ethanol. For water-soluble applications, its solubility can be improved through cyclodextrin inclusion complexation. This versatility makes it ideal for tablets, capsules, oral liquids, functional foods, and advanced skincare formulations.
Low Dosage, High Activity, and High Safety
Preclinical studies demonstrate an LD50 > 5000mg/kg (oral administration to rats), indicating no acute toxicity or genotoxicity. The recommended human dosage is merely 50-200mg/day to achieve therapeutic efficacy. This low effective dosage allows manufacturers to control formulation costs while delivering high-impact results.
Clean Label, Natural, and Additive-Free
Extracts China guarantees that our Nobiletin Powder is entirely free of preservatives, artificial pigments, fragrances, and solvent residues. It perfectly aligns with the "clean label" trend, meeting the stringent formulation needs of high-end functional foods, premium dietary supplements, and natural skincare lines.
Why Partner with Extracts China?
Quality and compliance are the cornerstones of our B2B service. Extracts China operates a state-of-the-art manufacturing facility certified for ISO22000, HACCP, and HALAL standards. Production strictly occurs within a Class 100,000 cleanroom environment. From raw material intake to finished product release, we enforce 12 meticulous quality control checkpoints. These monitor purity, particle size, and microorganisms (including total bacterial count, mold, and Salmonella) in real-time.
Our R&D division is led by PhDs in food science and natural product chemistry, backed by over a decade of specialized research in citrus flavonoids. We provide one-stop technical services, including formulation development, process optimization, literature support, and compliance consulting. Our products comply with Chinese GB2760, US FDA GRAS, and EU EFSA standards. We readily provide certificates of origin, free sale certificates, and HALAL/KOSHER certifications, fully supporting compliant sales and distribution in the global market.
Packaging, Storage, and Delivery
To preserve the chemical integrity of Nobiletin Powder, it should be stored in a cool, dry place away from direct sunlight. We offer flexible packaging options tailored to B2B wholesale requirements, ensuring safe transit and shelf-life stability.
| Quantity (Kilograms) | Est. Delivery Time (Days) |
|---|---|
| 1 - 10 | 3 |
| 10 - 50 | 5 |
| > 50 | Negotiation |
Contact Us for Bulk Nobiletin Powder
Extracts China is your trusted ingredient partner, specializing in high-quality herbal extract powders and nutritional supplement raw materials. With over six years of dedication to research, development, production, and global distribution, our mission is to deliver unique, cost-effective, and ecologically responsible products to our clients.
To request a free sample or request a wholesale quote for Nobiletin Powder, please contact our dedicated sales team:
Email: [email protected]
